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ReModelin

Product Name
ReModelin
CAS No.
949912-58-7
Chemical Name
ReModelin
Synonyms
CS-2149;ReModelin;Reaxys ID: 18559527;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
CBNumber
CB92729373
Molecular Formula
C15H14N4S
Formula Weight
282.36
MOL File
949912-58-7.mol
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ReModelin Property

Boiling point:
498.9±47.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
14.40±0.20(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1112
Product name
Remodelin hydrobromide
Purity
≥98% (HPLC)
Packaging
5mg
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1112
Product name
Remodelin hydrobromide
Purity
≥98% (HPLC)
Packaging
25mg
Price
$214
Updated
2024/03/01
Sigma-Aldrich
Product number
5.31066
Product name
Remodelin
Packaging
25MG
Price
$260
Updated
2024/03/01
Cayman Chemical
Product number
17346
Product name
Remodelin
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17346
Product name
Remodelin
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
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ReModelin Chemical Properties,Usage,Production

Description

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.

Uses

Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.

storage

Store at +4°C

References

1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

ReModelin Preparation Products And Raw materials

Raw materials

Preparation Products

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ReModelin Suppliers

China 82 The Netherlands 1 United Kingdom 2 United States 11 Global 96
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from ReModelin manufacturers

Career Henan Chemical Co
Product
ReModelin 949912-58-7
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

949912-58-7, ReModelinRelated Search:

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  • ReModelin
  • 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
  • 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
  • CS-2149
  • Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-
  • Reaxys ID: 18559527
  • 4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile
  • 4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile
  • 949912-58-7